Hereditary Endocrine Cancer: A Model Based on Phaeochromocytoma – Paraganglioma Syndromes

Grant number: 1108032 | Funding period: 2016 - 2018

Completed

Abstract

Phaeochromocytomas and paragangliomas are tumours remarkable for their very high heritability. They have a high burden of disease themselves, and their associated hereditary syndromes include risks for other malignancies. Our study will rationalize the pathological approach to diagnosing these hereditary syndromes, find new therapeutic targets for metastatic disease, and provide a template for other cancers with high heritable component.

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Background Until recently, determining penetrance required large observational cohort studies. Data from the Exome Aggregate Conso..

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University of Melbourne Researchers

Richard Tothill